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SLU-PP-332 is a novel ERR agonist known as an “exercise mimetic.” Discover how it supports mitochondrial biogenesis and metabolic efficiency.
SLU-PP-332 features a compact aromatic scaffold with a pyrrole-indole core substituted by phenyl and amide groups, conferring its selectivity for ERR binding; its molecular formula is C18H14N2O2, with a molecular weight of 290.3 g/mol. This structure is designed for bioavailability and cellular penetration. While the raw compound supports solubility in organic solvents, our encapsulation ensures it is protected during digestion for delivery to the intestinal tract. Our preparations achieve purity levels exceeding 98% by HPLC, with consistent batch-to-batch reproducibility that we document transparently, ensuring you have reliable materials at hand.
SLU-PP-332 is a synthetic small-molecule agonist of the estrogen-related receptors (ERRs), particularly potent at ERRα, designed to activate transcriptional programs that mimic the metabolic adaptations of aerobic exercise. By engaging ERRα, β, and γ isoforms, it promotes mitochondrial biogenesis, enhances fatty acid oxidation, and boosts energy expenditure. This compound is positioned as a valuable tool for supporting metabolic regulation, oxidative metabolism, and cellular resilience to stressors. It provides a chemical signal that encourages the body's cellular machinery to adopt a more efficient, endurance-adapted state, even in the absence of physical load.
In mechanistic terms, SLU-PP-332 binds to ERRs with high affinity (EC50 of 98 nM for ERRα), inducing a gene expression profile akin to endurance training. This upregulation affects pathways involved in lipid metabolism, the Krebs cycle, and oxidative phosphorylation. This activation shifts cellular fuel preference toward fats, reducing reliance on glucose and helping to mitigate lipid accumulation. Mechanistically, it elevates the expression of PGC-1α coactivators and mitochondrial markers like OXPHOS subunits, fostering a more efficient energy-producing state—we're happy to walk through the data behind these metabolic shifts, offering straightforward interpretations grounded in the science.
In summary, SLU-PP-332 emerges as a precise tool for supporting ERR-mediated metabolic pathways, enabling a chemical simulation of exercise-like benefits and illuminating strategies for optimizing energy dynamics with clarity and control. Its role in enhancing mitochondrial function and fatty acid oxidation underscores our quiet enthusiasm for compounds that bridge basic science and practical potential, all while upholding the highest standards of quality. SLU-PP-332 reflects our humble dedication to empowering your wellness and discovery through accessible, evidence-driven support. Let's chat about integrating it into your regimen, one measured insight at a time.
SLU-PP-332's unique ability to agonize ERRs makes it a subject of significant interest for metabolic remodeling. In liver models, it has been shown to attenuate lipid droplet formation and enhance β-oxidation, mechanisms relevant to hepatic health. In adipose tissue, the compound helps reduce triglyceride storage and promotes browning-like phenotypes, providing insights into energy balance. Skeletal muscle systems benefit from its induction of mitochondrial density and capillary-like networks, mimicking the adaptations seen in endurance training or combating sarcopenia. Additionally, its role in optimizing mitochondrial function supports glucose homeostasis. We appreciate the nuance in these biological actions and are here to provide insights into how this "exercise in a pill" mechanism functions, keeping things logical and approachable.
For optimal stability, store SLU-PP-332 capsules in a cool, dry environment, preferably at room temperature or 4°C, keeping the container tightly sealed to shield from humidity and light. If extracting contents for specific applications, note that the compound is stable but should be handled with care to maintain purity. Backed by our stability validations, these steps help maintain integrity—reach out if you have questions regarding handling or storage.
